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Zai Lab (09688.HK) Enters Global Collaboration with Amgen (AMGN.US) to Explore Novel ADC and BiTE Combination Therapy
Zai Lab (09688.HK) announced that it has entered into a global clinical research collaboration with Amgen (AMGN.US) to evaluate Zai Labs clinical-stage delta-like ligand 3 (DLL3)-...
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Zai Lab (09688.HK) Enters Global Collaboration with Amgen (AMGN.US) to Explore Novel ADC and BiTE Combination Therapy
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Zai Lab (09688.HK)  +0.030 (+0.221%)    Short selling $22.14M; Ratio 20.958%   announced that it has entered into a global clinical research collaboration with Amgen (AMGN.US)      to evaluate Zai Labs clinical-stage delta-like ligand 3 (DLL3)-targeted antibody-drug conjugate Zocilurtatug Pelitecan (zoci, formerly known as ZL-1310) in combination with Amgens IMDELLTRA?(tarlatamab), a DLL3-targeted bispecific T-cell engager (BiTE? therapy, for the treatment of patients with extensive-stage small cell lung cancer (ES-SCLC).

As part of the collaboration agreement, Amgen will sponsor a global Phase 1b study to assess the safety and efficacy of zoci in combination with IMDELLTRA?in patients with ES-SCLC. Zai Lab will retain full ownership of zoci and will supply the investigational drug for the clinical study to Amgen.

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Dr. Rafael G. Amado, President and Head of Global Research and Development at Zai Lab, stated that this dual-target combination strategy is expected to enhance systemic and intracranial response rates and depth of response, address resistance mechanisms, and establish a new treatment paradigm for patients with small cell lung cancer. The two therapies leverage complementary mechanisms of action. (ec/u)(HK stocks quote is delayed for at least 15 mins.Short Selling Data as at 2026-06-02 16:25.) (Real-time Streaming US Stocks Quote; Except All OTC quotes are at least 15 minutes delayed.)

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